Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer.

ABSTRACT:

Purpose

To develop a radiomics prediction model to improve pulmonary nodule (PN) classification in low-dose CT. To compare the model with the American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) for early detection of lung cancer.

Methods

We examined a set of 72 PNs (31 benign and 41 malignant) from the Lung Image Database Consortium image collection (LIDC-IDRI). One hundred three CT radiomic features were extracted from each PN. Before the model building process, distinctive features were identified using a hierarchical clustering method. We then constructed a prediction model by using a support vector machine (SVM) classifier coupled with a least absolute shrinkage and selection operator (LASSO). A tenfold cross-validation (CV) was re

SUBMITTER: Choi W 

PROVIDER: S-EPMC5903960 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature