Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization.

ABSTRACT:

Purpose

The etiology of fertilization failure and polyspermy during assisted reproductive technology (ART) remains elusive. The aim of this study was to determine whether mutations in the IZUMO1 receptor (IZUMO1R) gene, which is essential for mammalian fertilization, contribute to the pathogenesis of fertilization failure or polyspermy in humans.

Methods

We recruited 215 female subjects with fertilization failure/poor fertilization, 330 females with polyspermy, and 300 matched controls. All subjects underwent IVF treatment. Peripheral blood DNA of cases was extracted and screened for mutations in IZUMO1R gene.

Results

Four rare single nucleotide polymorphisms (SNPs) of the IZUMO1R were identified among specimens from patients with fertilization failure and polyspermy

SUBMITTER: Yu M 

PROVIDER: S-EPMC5904069 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature