Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia.

ABSTRACT: Given its high penetrance, clearly delineated and evolutionary conserved genomic structure, mouse models of the 22q11.2 deletion provide an ideal organism-based and cell-based model of this well-established disease mutation for schizophrenia. In this study we examined the development of changes in intrinsic properties, action potential firing and synaptic transmission using whole-cell patch-clamp recordings of cultured embryonic cortical neurons from Df(16)A ^+/- and WT mice at DIV7 and DIV14, respectively. Compared to neurons from the WT littermates, significantly increased input resistance and decreased rising rate of action potential was observed in Df(16)A ^+/- mice at DIV7 but not at DIV14 indicative of delayed neuronal maturation. Neurons from Df(16)A ^+/-

SUBMITTER: Sun Z 

PROVIDER: S-EPMC5904157 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature