Tissue-specific transcriptome profiling of <i>Drosophila</i> reveals roles for GATA transcription factors in longevity by dietary restriction.

ABSTRACT: Dietary restriction (DR) extends animal lifespan, but imposes fitness costs. This phenomenon depends on dietary essential amino acids (EAAs) and TOR signalling, which exert systemic effects. However, the roles of specific tissues and cell-autonomous transcriptional regulators in diverse aspects of the DR phenotype are unknown. Manipulating relevant transcription factors (TFs) specifically in lifespan-limiting tissues may separate the lifespan benefits of DR from the early-life fitness costs. Here, we systematically analyse transcription across organs of Drosophila subjected to DR or low TOR and predict regulatory TFs. We predict and validate roles for the evolutionarily conserved GATA family of TFs, and identify conservation of this signal in mice. Importantly, restricting knockdown

SUBMITTER: Dobson AJ 

PROVIDER: S-EPMC5904217 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature