Allergic T_H2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4⁺ T Cells.

ABSTRACT: Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate T_H2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4⁺ T cell-derived memory T_H2 cells. To investigate Bcl6 function in allergic responses in naturally occurring memory phenotype CD4⁺ T (MPT) cells and their derived T_H2 (MPT_H2) cells, Bcl6-manipulated mice, highly conserved intron enhancer (hcIE)-deficient mice, and reporter mice for conserved noncoding sequence 2 (CNS2) 3' distal enhancer region were used to elucidate Bcl6 function in MPT cells. The molecular mechanisms of Bcl6-mediated T_H2 cytokine gene regulation were elucidated using

SUBMITTER: Ogasawara T 

PROVIDER: S-EPMC5904433 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature