Common genetic variation and novel loci associated with volumetric mammographic density.

ABSTRACT:

Background

Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained.

Methods

We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations with volumetric MD phenotypes (percent dense volume, absolute dense volume, and absolute nondense volume) were estimated using linear regression adjusting for age, body mass index, menopausal status, and six principal components. We also estimated the proportion of MD variance explained by additive contributions from single-nucleotide polymorphisms (SNP-based heritability [h²_SNP]) in 4948 participants of the cohort.

Results

In total,

SUBMITTER: Brand JS 

PROVIDER: S-EPMC5904990 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature