An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides.

ABSTRACT:

Background

Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the skin, alternatively-activated (M2a) macrophages, and to lesser extents by several other types of tissues. CLEC10A is an endocytic receptor on antigen-presenting cells and has been proposed to play an important role in maturation of dendritic cells and initiation of an immune response. In this study, we asked whether a peptide that binds in the GalNAc-binding site of CLEC10A would serve as an effective tool to activate an immune response against ovarian cancer.

Method

SUBMITTER: Eggink LL 

PROVIDER: S-EPMC5905120 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature