Plasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses.

ABSTRACT:

Background

In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies for merozoite surface protein (msp) variants increases the information available in the data, allowing multiple infecting parasite clones in a single individual to be identified. msp genotyped samples from two longitudinal cohorts in Papua New Guinea (PNG) and Thailand were analysed using a statistical model where the times of acquisition and clearance of each clone in every individual were estimated using a process of data augmentation.

Results

For the populations analysed, the duration of blood-stage P. falciparum infection was estimated as 36 (95% Credible Interval (CrI

SUBMITTER: White MT 

PROVIDER: S-EPMC5905131 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature