Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturation.

ABSTRACT: BACKGROUND:Neuron maturation is a critical process in neurogenesis, during which neurons gain their morphological, electrophysiological and molecular characteristics for their functions as the central components of the nervous system. RESULTS:To better understand the molecular changes during this process, we combined the protein-protein interaction network and public single cell RNA-seq data of mature and immature neurons to identify functional modules relevant to the neuron maturation process in humans. Among the 109 functional modules in total, 33 showed significant gene expression level changes (discriminating modules) which participate in varied functions including energy consumption, synaptic functions and housekeeping functions such as translation and splicing. Based on the identifie

SUBMITTER: He Z 

PROVIDER: S-EPMC5905132 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature