Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA.

ABSTRACT: BACKGROUND:Alterations in inflammatory cytokines and genetic background of the host contribute to the outcome of malaria infection. Despite the promising protective role of IL-17 in infections, little attention is given to further understand its importance in the pathogenesis of severe malaria anaemia in chronic/endemic situations. The objective of this study, therefore, was to evaluate IL-17 levels in anaemic condition and its association with host genetic factors. METHODS:Two mice strains (Balb/c and CBA) were crossed to get the F1 progeny, and were (F1, Balb/c, CBA) taken through 6 cycles of Plasmodium berghei (ANKA strain) infection and chloroquine/pyrimethamine treatment to generate semi-immune status. Cytokine levels and kinetics of antibody production, CD4+CD25+T regulatory cells we

SUBMITTER: Helegbe GK 

PROVIDER: S-EPMC5905139 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature