Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations.

ABSTRACT:

Background

Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were selected to evaluate their association and prevalence in a Saudi Arabian patient cohort with chronic kidney disease (CKD).

Methods

Eight genetic variants in four genes (SHROOM3, MYH9, SLC7A9, and CST3) were genotyped in 160 CKD patients and 189 ethnicity-matched healthy controls. Genetic variants were tested for association with the development of CKD (eGFR < 60 ml/min/1.73m²) and effects were compared with results obtained from 133,413 participants in the CKD genetics consortium. Multivariable regression was used to evaluate the role of these eight v

SUBMITTER: Cyrus C 

PROVIDER: S-EPMC5905143 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature