A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders.

ABSTRACT:

Background

Mutations in the SHANK genes, which encode postsynaptic scaffolding proteins, have been linked to a spectrum of neurodevelopmental disorders. The SHANK genes and the schizophrenia-associated microRNA-137 show convergence on several levels, as they are both expressed at the synapse, influence neuronal development, and have a strong link to neurodevelopmental and neuropsychiatric disorders like intellectual disability, autism, and schizophrenia. This compiled evidence raised the question if the SHANKs might be targets of miR-137.

Methods

In silico analysis revealed a putative binding site for microRNA-137 (miR-137) in the SHANK2 3'UTR, while this was not the case for SHANK1 and SHANK3. Luciferase reporter assays were performed by overexpressing wild type and mutated

SUBMITTER: de Sena Cortabitarte A 

PROVIDER: S-EPMC5905159 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature