Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.

ABSTRACT:

Background

Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To this end, we performed a comprehensive proteomic analysis of blood plasma, with the scope to identify disease-associated changes after placing them in the context of existing knowledge, and generate a well characterized dataset for further use in CVD multi-omics integrative analysis.

Methods

LC-MS/MS was employed to analyze plasma from 32 subjects (19 cases of various CVD phenotypes and 13 controls) in two steps: discovery (13 cases and 8 controls) and test (6 cases and 5 controls) set analysis. Following label-free quantification, the detected proteins were cor

SUBMITTER: Lygirou V 

PROVIDER: S-EPMC5905170 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature