Effects of Diets with Different Proportions of Protein/Carbohydrate on Retinal Manifestations in db Mice.

ABSTRACT:

Background/aim

Diabetic nephropathy is aggravated by a higher intake of total protein. The effects of diets with different proportions of protein and carbohydrate on diabetic retinopathy in db mice, a type-2 diabetes animal model, were examined, as well as diabetic nephropathy.

Materials and methods

Control and db mice at 5 weeks of age were fed the diets (% energy of protein/carbohydrate/fat; L-diet: 12/71/17; H-diet: 24/59/17) under ad libitum conditions and pair-feeding conditions for 6 weeks, respectively.

Results

Mice fed the H-diet showed significantly greater retinal thickness by optical coherence tomography, and lower mRNA levels of angiotensinogen. Comparing combinations of diets and genotypes, db-H mice showed significantly higher mRNA levels of angiotensin-

SUBMITTER: Arimura E 

PROVIDER: S-EPMC5905193 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature