Ontology highlight
ABSTRACT:
SUBMITTER: Bari S
PROVIDER: S-EPMC5905230 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Stem cells translational medicine 20180202 5
Umbilical cord blood (UCB) transplants in adults have slower hematopoietic recovery compared to bone marrow (BM) or peripheral blood (PB) stem cells mainly due to low number of total nucleated cells and hematopoietic stem and progenitor cells (HSPC). As such in this study, we aimed to perform ex vivo expansion of UCB HSPC from non-enriched mononucleated cells (MNC) using novel azole-based small molecules. Freshly-thawed UCB-MNC were cultured in expansion medium supplemented with small molecules ...[more]