Association of expression of DRD2 rs1800497 polymorphism with migraine risk in Han Chinese individuals.

ABSTRACT:

Background

Previous studies suggested that single-nucleotide polymorphisms in dopamine receptor D2 (DRD2) are the susceptibility loci for migraine. This study was aimed at evaluating the contribution of DRD2 rs1800497 and its expression to migraine risk in Han Chinese subjects.

Methods

In total, 250 patients with migraine and 250 age- and sex-matched control subjects were included in this study. TaqMan allelic discrimination assay was used for DRD2 rs1800497 genotyping. Plasma DRD2 concentration was determined using enzyme-linked immunosorbent assay.

Results

Significant associations were observed for the rs1800497 genotype (c²=6.37, p=0.041) and allele (c²=4.69, p=0.03; odds ratio [OR]=1.33, 95% CI

SUBMITTER: Deng Y 

PROVIDER: S-EPMC5905461 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature