Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma.

ABSTRACT:

Purpose

Retinal ganglion cell (RGC) death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG), we investigated the association between plasma levels of TNF-α and POAG or its clinical indices in comparison to non-glaucomatous controls.

Patients and methods

In a case-control retrospective cohort of 51 POAG cases and 88 controls, plasma TNF-α levels were measured using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on an automated ELISA analyzer.

Results

Mean TNF-α leve

SUBMITTER: Kondkar AA 

PROVIDER: S-EPMC5905466 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature