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Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma.


ABSTRACT: Purpose:Retinal ganglion cell (RGC) death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-?), a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG), we investigated the association between plasma levels of TNF-? and POAG or its clinical indices in comparison to non-glaucomatous controls. Patients and methods:In a case-control retrospective cohort of 51 POAG cases and 88 controls, plasma TNF-? levels were measured using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on an automated ELISA analyzer. Results:Mean TNF-? level was significantly elevated in POAG cases (1.88 ± 2.17 pg/mL) than the controls (0.93 ± 1.49 pg/mL; p = 0.003). The overall dose-response trend was significant (?2 = 6.12, df = 2; p = 0.047). No statistical difference was seen in age, gender and systemic disease distribution. A modest negative and significant correlation was seen between TNF-? level and number of antiglaucoma medications, an important clinical index of POAG severity. Moreover, logistic regression analysis showed that the risk of POAG was most significantly affected by TNF-? level and not by age and sex. Conclusion:High systemic level of an inflammatory cytokine, TNF-?, is associated with POAG; however, its possible use as a biomarker for early glaucoma diagnosis and/or disease severity needs further investigation.

SUBMITTER: Kondkar AA 

PROVIDER: S-EPMC5905466 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma.

Kondkar Altaf A AA   Sultan Tahira T   Almobarak Faisal A FA   Kalantan Hatem H   Al-Obeidan Saleh A SA   Abu-Amero Khaled K KK  

Clinical ophthalmology (Auckland, N.Z.) 20180412


<h4>Purpose</h4>Retinal ganglion cell (RGC) death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG), we investigated the association between plasma levels of TNF-α and POAG or its clinical indices in comparison to non-glaucomato  ...[more]

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