Investigation of LEP and LEPR polymorphisms with the risk of hepatocellular carcinoma: a case-control study in Eastern Chinese Han population.

ABSTRACT:

Background

Leptin (LEP) and LEP receptor (LEPR) polymorphisms may be associated with the development of cancer.

Methods

In this study, we selected five functional LEP and LEPR single-nucleotide polymorphisms (SNPs) and conducted a case-control study to determine the relationship of LEP and LEPR polymorphisms with hepatocellular carcinoma (HCC) risk in Eastern Chinese Han population. There were 584 HCC cases and 923 cancer-free controls included in our study. HCC patients and controls were fully matched by age and sex. SNPscan™ genotyping method was used to analyze the genotyping of LEP rs2167270 G>A, rs7799039 A>G, LEPR rs6588147 G>A, rs1137100 G>A, and rs1137101 G>A SNPs.

Results

We found that LEP rs77990

SUBMITTER: Zhang S 

PROVIDER: S-EPMC5905468 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature