Identifying functionally informative evolutionary sequence profiles.

ABSTRACT:

Motivation

Multiple sequence alignments (MSAs) can provide essential input to many bioinformatics applications, including protein structure prediction and functional annotation. However, the optimal selection of sequences to obtain biologically informative MSAs for such purposes is poorly explored, and has traditionally been performed manually.

Results

We present Selection of Alignment by Maximal Mutual Information (SAMMI), an automated, sequence-based approach to objectively select an optimal MSA from a large set of alternatives sampled from a general sequence database search. The hypothesis of this approach is that the mutual information among MSA columns will be maximal for those MSAs that contain the most diverse set possible of the most structurally and functionally hom

SUBMITTER: Gil N 

PROVIDER: S-EPMC5905606 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature