Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

ABSTRACT:

Background

Early treatment with valproic acid (VPA) has demonstrated benefit in preclinical models of traumatic brain injury, including smaller brain lesion size, decreased edema, reduced neurologic disability, and faster recovery. Mechanisms underlying these favorable outcomes are not fully understood. We hypothesized that VPA treatment would upregulate genes involved in cell survival and proliferation and downregulate those associated with cell death and the inflammatory response.

Methods

Ten female swine were subjected to a protocol of traumatic brain injury and hemorrhagic shock. They were assigned to two groups (n = 5): normal saline (NS; 3× volume of shed blood), or NS + VPA (150 mg/kg). Following 6 hours of observation, brain tissue was harvested to evaluate lesion si

SUBMITTER: Nikolian VC 

PROVIDER: S-EPMC5905703 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature