Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells.

ABSTRACT: Pluripotent stem cell-derived endothelial cells (ECs) have great potential to be used in vascular therapy or tissue engineering. It is also much desired to obtain arterial or venous ECs for specific applications. Factors that are critical for the proper arterial or venous differentiation from pluripotent stem cells still need to be understood. Here, we aim at investigating this problem deeper by examining neuropilin-1 (Nrp1), an early arterial marker that may be critical for arterial cell fate commitment. Using murine embryonic stem cells as the model system, this study investigates the neuropilin-1 (Nrp1) expression during the differentiation of pluripotent stem cells toward a vascular progenitor population. We hypothesize that Nrp1, an early arterial marker present in a developing embryo

SUBMITTER: Kim D 

PROVIDER: S-EPMC5905878 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature