Cost-effectiveness of alternative strategies for provision of HIV preexposure prophylaxis for people who inject drugs.

ABSTRACT:

Background

Oral HIV preexposure prophylaxis (PrEP) has been recommended as a means of HIV prevention among people who inject drugs (PWIDs) but, at current prices, is unlikely to be cost-effective for all PWID.

Objective

To determine the cost-effectiveness of alternative strategies for enrolling PWID in PrEP.

Design

Dynamic network model that captures HIV transmission and progression among PWID in a representative US urban center.

Outcome measures

HIV infections averted, discounted costs and quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios.

Intervention

We assume 25% PrEP coverage and investigate four strategies: first, random PWID are enrolled (Unselected Enrollment); second, individuals are randomly selected and enrolled to

SUBMITTER: Fu R 

PROVIDER: S-EPMC5906044 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature