Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure.

ABSTRACT: Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion, and tissue homeostasis in engineered organs pose challenges. We hypothesized that decellularized human placenta will be suitable for tissue engineering. The universal availability and unique structures of placenta for accommodating tissue, including presence of embedded vessels, were major attractions. We found decellularized placental vessels were reendothelialized by adjacent native cells and bridged vessel defects in rats. In addition, implantation of liver fragments containing all cell types successfully hepatized placenta with maintenance of albumin and urea s

SUBMITTER: Kakabadze Z 

PROVIDER: S-EPMC5906146 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature