Inflammation and Trajectory of Renal Function in Community-Dwelling Older Adults.

ABSTRACT:

Objectives

To examine the hypothesis that the inflammatory state of aging is a risk factor for accelerated renal function (RF) decline using inflammatory biomarkers and RF measures collected over 9 years of follow-up in relatively healthy individuals enrolled in the Invecchiare in Chianti study.

Design

Longitudinal.

Setting

Community.

Participants

Individuals aged 60 and older with baseline estimated glomerular filtration rate (eGFR) of 60 mL/min per 1.73 m² and greater and no diabetes mellitus (DM) (N = 687).

Measures

eGFR, as a proxy for RF, was determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at baseline and 3-, 6-, and 9-year follow-up. Incident chronic kidney disease (CKD) was defined as new-onset

SUBMITTER: Salimi S 

PROVIDER: S-EPMC5906158 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature