Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ABSTRACT: Cleft palate (CP) is the most prevalent craniofacial deformity, with ethnic and geographic variation in prevalence in humans. Mice have been used as an animal model to study the cause(s) of CP by several approaches, including genetic and chemical-induced approaches. Mouse genetic approaches revealed that significant amounts of genes are involved in the CP pathology. The aim of this study was to identify common features of CP-associated genes and to explore the roles of microRNAs (miRNAs) as important post-transcriptional regulators that may be involved in the regulation of CP genes. To generate an accurate list of genes associated with CP, we first conducted systematic literature searches through main databases such as Medline, Embase, and PubMed, as well as other sources such as Scopus an

SUBMITTER: Suzuki A 

PROVIDER: S-EPMC5906164 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature