Personality Changes During the Transition from Cognitive Health to Mild Cognitive Impairment.

ABSTRACT:

Background/objectives

Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI).

Design

Longitudinal observational cohort study.

Setting

Academic medical center.

Participants

Members of an apolipoprotein E (APOE) ɛ4 genetically enriched cohort of Maricopa County residents who were neuropsychiatrically healthy at entry (N = 277). Over a mean interval of 7 years, 25 who developed MCI an

SUBMITTER: Caselli RJ 

PROVIDER: S-EPMC5906173 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature