Bleeding complications in acute liver failure.

ABSTRACT: In patients with acute liver failure (ALF), elevated prothrombin time and thrombocytopenia can fuel a perception of a bleeding tendency. However, the incidence, site, risk factors, and clinical significance of bleeding complications have not been quantified in a large cohort of patients with ALF. We studied 1,770 adult patients enrolled in the ALF Study Group Registry between 1998 and 2016. Bleeding complications and blood component transfusions were collected for 7 days after admission. The relationship of bleeding complications to 21-day mortality was assessed. Despite a median international normalized ratio of 2.7 and platelet count of 96 × 10⁹ /L on admission, bleeding complications were observed in only 187 patients (11%), including 173 spontaneous and 22 postprocedural ble

SUBMITTER: Stravitz RT 

PROVIDER: S-EPMC5906191 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature