Selective inhibition of M₅ muscarinic acetylcholine receptors attenuates cocaine self-administration in rats.

ABSTRACT: Cocaine use disorder (CUD) remains a debilitating health problem in the United States for which there are no Food and Drug Administration-approved treatment options. Accumulating anatomical and electrophysiological evidence indicates that the muscarinic acetylcholine receptor (mAChR) subtype 5 (M₅ ) plays a critical role in the regulation of the mesolimbic dopaminergic reward circuitry, a major site of action for cocaine and other psychostimulants. In addition, M₅ knockout mice exhibit reduced cocaine self-administration behaviors with no differences in sugar pellet-maintained responding relative to wild-type mice. These findings suggest that selective inhibition of M₅ mAChR may provide a novel pharmacological approach for targeting CUD. Recently, we report

SUBMITTER: Gunter BW 

PROVIDER: S-EPMC5906200 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature