Automated fluid delivery from multiwell plates to microfluidic devices for high-throughput experiments and microscopy.

ABSTRACT: High-throughput biological and chemical experiments typically use either multiwell plates or microfluidic devices to analyze numerous independent samples in a compact format. Multiwell plates are convenient for screening chemical libraries in static fluid environments, whereas microfluidic devices offer immense flexibility in flow control and dynamics. Interfacing these platforms in a simple and automated way would introduce new high-throughput experimental capabilities, such as compound screens with precise exposure timing. Whereas current approaches to integrate microfluidic devices with multiwell plates remain expensive or technically complicated, we present here a simple open-source robotic system that delivers liquids sequentially through a single connected inlet. We first characteriz

SUBMITTER: Lagoy RC 

PROVIDER: S-EPMC5906459 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature