Prediction of Cell-Penetrating Potential of Modified Peptides Containing Natural and Chemically Modified Residues.

ABSTRACT: Designing drug delivery vehicles using cell-penetrating peptides is a hot area of research in the field of medicine. In the past, number of in silico methods have been developed for predicting cell-penetrating property of peptides containing natural residues. In this study, first time attempt has been made to predict cell-penetrating property of peptides containing natural and modified residues. The dataset used to develop prediction models, include structure and sequence of 732 chemically modified cell-penetrating peptides and an equal number of non-cell penetrating peptides. We analyzed the structure of both class of peptides and observed that positive charge groups, atoms, and residues are preferred in cell-penetrating peptides. In this study, models were developed to predict cell-penet

SUBMITTER: Kumar V 

PROVIDER: S-EPMC5906597 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature