Mitochondrial function in individuals at clinical high risk for psychosis.

ABSTRACT: Alterations in mitochondrial function have been implicated in the etiology of schizophrenia. Most studies have investigated alterations in mitochondrial function in patients in which the disorder is already established; however, whether mitochondrial dysfunction predates the onset of psychosis remains unknown. We measured peripheral mitochondrial complex (I-V) function and lactate/pyruvate levels in 27 antipsychotic-naïve individuals at clinical high risk for psychosis (CHR) and 16 healthy controls. We also explored the association between mitochondrial function and brain microglial activation and glutathione levels using a translocator protein 18 kDa [¹⁸F]FEPPA PET scan and ¹H-MRS scan, respectively. There were no significant differences in mitochondrial complex func

SUBMITTER: Da Silva T 

PROVIDER: S-EPMC5906614 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature