Motion model ultrasound localization microscopy for preclinical and clinical multiparametric tumor characterization.

ABSTRACT: Super-resolution imaging methods promote tissue characterization beyond the spatial resolution limits of the devices and bridge the gap between histopathological analysis and non-invasive imaging. Here, we introduce motion model ultrasound localization microscopy (mULM) as an easily applicable and robust new tool to morphologically and functionally characterize fine vascular networks in tumors at super-resolution. In tumor-bearing mice and for the first time in patients, we demonstrate that within less than 1 min scan time mULM can be realized using conventional preclinical and clinical ultrasound devices. In this context, next to highly detailed images of tumor microvascularization and the reliable quantification of relative blood volume and perfusion, mULM provides multiple new functiona

SUBMITTER: Opacic T 

PROVIDER: S-EPMC5906644 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature