Starvation during pregnancy impairs fetal oogenesis and folliculogenesis in offspring in the mouse.

ABSTRACT: Although it is becoming increasingly evident that maternal starvation during pregnancy can have permanent effects on a range of physiological processes in the offspring, scant information is available about the consequence of such condition for oogenesis and hence for lifetime reproductive success of progeny in mammals. In the present study, we address this topic by starving pregnant mice at the time of ovarian differentiation (12.5 days post coitum (dpc)) for three consecutive days and analyzed the consequence first on the survival of the fetal oocytes and their capability to progress throughout the stages of meiotic prophase I (MPI) and then on the postnatal folliculogenesis of the offspring. The results showed that maternal starvation increased apoptosis in the fetal ovaries, resulting

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC5906686 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature