A four-microRNA classifier as a novel prognostic marker for tumor recurrence in stage II colon cancer.

ABSTRACT: About 20 percent of TNM-stage II colon cancer patients who are treated by surgical resection develop recurrence, and adjuvant chemotherapy in this group is still debated among researchers and clinicians. Currently, adverse histopathological and clinical factors are used to select patients for adjuvant chemotherapy following surgery. However, additional biomarkers to classify patients at risk of recurrence are needed. We have conducted a study using fresh frozen tumor tissue from 54 TNM-stage II colon cancer patients and performed microRNA profiling using next-generation sequencing. For the selection of the prognostic microRNAs, a LASSO Cox Regression model was employed. For the validation, we used the publically available TCGA-COAD cohort (n = 122). A prognostic panel of four micorRNAs (hs

SUBMITTER: Jacob H 

PROVIDER: S-EPMC5906690 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature