UDP-sugars activate P2Y₁₄ receptors to mediate vasoconstriction of the porcine coronary artery.

ABSTRACT:

Aims

UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y₁₄ receptor is a G_i/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In this study we sought to investigate whether P2Y₁₄ receptors are functionally expressed in the porcine coronary artery using a selective P2Y₁₄ receptor agonist, MRS2690, and a novel selective P2Y₁₄ receptor antagonist, PPTN (4,7-disubstituted naphthoic acid derivative).

Methods and results

Isometric tension recordings were used to evaluate the effects of UDP-sugars in porcine isolated coronary artery segments. The effects of the P2 receptor antagonists suramin and PPADS, the P2Y

SUBMITTER: Abbas ZSB 

PROVIDER: S-EPMC5906693 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature