Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.

ABSTRACT:

Objectives

Apathy is among the earliest and most pervasive neuropsychiatric symptoms in prodromal and mild Alzheimer disease (AD) dementia that correlates with functional impairment and disease progression. We investigated the association of apathy with regional 18F-fluorodeoxyglucose (FDG) metabolism in cognitively normal, mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative database.

Design

Cross-sectional and longitudinal studies.

Setting

57 North American research sites.

Participants

402 community dwelling elders.

Measurements

Apathy was assessed using the Neuropsychiatric Inventory Questionnaire. Baseline FDG metabolism in five regions implicated in the neurobiology of apathy and AD was investigate

SUBMITTER: Gatchel JR 

PROVIDER: S-EPMC5906700 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature