Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.

ABSTRACT: Healthy aging is associated with marked effects on sleep, including its daily amount and architecture, as well as the specific EEG oscillations. Neither the neurophysiological underpinnings nor the biological significance of these changes are understood, and crucially the question remains whether aging is associated with reduced sleep need or a diminished capacity to generate sufficient sleep. Here we tested the hypothesis that aging may affect local cortical networks, disrupting the capacity to generate and sustain sleep oscillations, and with it the local homeostatic response to sleep loss. We performed chronic recordings of cortical neural activity and local field potentials from the motor cortex in young and older male C57BL/6J mice, during spontaneous waking and sleep, as well as duri

SUBMITTER: McKillop LE 

PROVIDER: S-EPMC5907054 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature