Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis.

ABSTRACT: BACKGROUND:The success of clinical trials of selective B cell depletion in patients with relapsing multiple sclerosis (MS) indicates B cells are important contributors to peripheral immune responses involved in the development of new relapses. Such B cell contribution to peripheral inflammation likely involves antibody-independent mechanisms. Of growing interest is the potential that B cells, within the MS central nervous system (CNS), may also contribute to the propagation of CNS-compartmentalized inflammation in progressive (non-relapsing) disease. B cells are known to persist in the inflamed MS CNS and are more recently described as concentrated in meningeal immune-cell aggregates, adjacent to the subpial cortical injury which has been associated with progressive disease. How B cells ar

SUBMITTER: Touil H 

PROVIDER: S-EPMC5907187 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature