The Temporal Dynamics of Brain Plasticity in Aging.

ABSTRACT: Cognitive training has been suggested as a possible remediation of decline in brain structure with older age. However, it is unknown whether training effects are transient or enduring, as no studies have examined training-induced plasticity relative to decline in older adults across extended periods with multiple intervention phases. We investigated the temporal dynamics of brain plasticity across periods on and off memory training, hypothesizing that (1) a decline in white matter (WM) microstructure would be observed across the duration of the study and (2) that periods of memory training would moderate the WM microstructural decline. In total, 107 older adults followed a 40-week program, including 2 training periods separated by periods with no intervention. The general decline in WM mic

SUBMITTER: de Lange AG 

PROVIDER: S-EPMC5907343 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature