Parvalbumin-Positive Interneurons Regulate Neuronal Ensembles in Visual Cortex.

ABSTRACT: For efficient cortical processing, neural circuit dynamics must be spatially and temporally regulated with great precision. Although parvalbumin-positive (PV) interneurons can control network synchrony, it remains unclear how they contribute to spatio-temporal patterning of activity. We investigated this by optogenetic inactivation of PV cells with simultaneous two-photon Ca2+ imaging from populations of neurons in mouse visual cortex in vivo. For both spontaneous and visually evoked activity, PV interneuron inactivation decreased network synchrony. But, interestingly, the response reliability and spatial extent of coactive neuronal ensembles during visual stimulation were also disrupted by PV-cell suppression, which reduced the functional repertoire of ensembles. Thus, PV interneurons can

SUBMITTER: Agetsuma M 

PROVIDER: S-EPMC5907345 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature