BDNF-Dependent Effects on Amygdala-Cortical Circuitry and Depression Risk in Children and Youth.

ABSTRACT: The brain-derived neurotrophic factor (BDNF) is critical for brain development, and the functional BDNF Val66Met polymorphism is implicated in risk for mood disorders. The objective of this study was to determine how the Val66Met polymorphism influences amygdala-cortical connectivity during neurodevelopment and assess the relevance for mood disorders. Age- and sex-specific effects of the BDNF Val66Met polymorphism on amygdala-cortical connectivity were assessed by examining covariance of amygdala volumes with thickness throughout the cortex in a sample of Caucasian youths ages 8-22 that were part of the Philadelphia Neurodevelopmental Cohort (n = 339). Follow-up analyses assessed corresponding BDNF genotype effects on resting-state functional connectivity (n = 186) and the association betw

SUBMITTER: Wheeler AL 

PROVIDER: S-EPMC5907350 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature