Human Genomic Signatures of Brain Oscillations During Memory Encoding.

ABSTRACT: Memory encoding is an essential step for all learning. However, the genetic and molecular mechanisms underlying human memory encoding remain poorly understood, and how this molecular framework permits the emergence of specific patterns of brain oscillations observed during mnemonic processing is unknown. Here, we directly compare intracranial electroencephalography recordings from the neocortex in individuals performing an episodic memory task with human gene expression from the same areas. We identify genes correlated with oscillatory memory effects across 6 frequency bands. These genes are enriched for autism-related genes and have preferential expression in neurons, in particular genes encoding synaptic proteins and ion channels, supporting the idea that the genes regulating voltage gra

SUBMITTER: Berto S 

PROVIDER: S-EPMC5907355 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature