Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC. METHODS:PubMed, Embase, and the Cochrane Library databases were searched for observational studies evaluating the effect of metformin on EC prevention or treatment. The odds ratio (OR) was used for analyzing risks, and the hazard ratio (HR) was used for analyzing survival outcomes. A random-effects model was used for data analysis. RESULTS:Seven studies reported data on EC risk. The pooled results suggested that metformin was not significantly associated with a lower risk of EC [OR =

SUBMITTER: Chu D 

PROVIDER: S-EPMC5907461 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature