Ectopic Fgf signaling induces the intercalary response in developing chicken limb buds.

ABSTRACT:

Background

Intercalary pattern formation is an important regulatory step in amphibian limb regeneration. Amphibian limb regeneration is composed of multiple steps, including wounding, blastema formation, and intercalary pattern formation. Attempts have been made to transfer insights from regeneration-competent animals to regeneration-incompetent animalsat each step in the regeneration process. In the present study, we focused on the intercalary mechanism in chick limb buds. In amphibian limb regeneration, a proximodistal axis is organized as soon as a regenerating blastema is induced. Intermediate structures are subsequently induced (intercalated) between the established proximal and distal identities. Intercalary tissues are derived from proximal tissues. Fgf signaling mediates th

SUBMITTER: Makanae A 

PROVIDER: S-EPMC5907462 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature