Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.

ABSTRACT:

Background

Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change.

Methods and results

Genome-wide analysis of glucose change after treatment with chlorthalidone was performed by race among the white (n=175) and black (n=135) participants from the PEAR-2 (Pharmacogenomic Evaluation of Antihypertensive Responses-2). Single-nucleotide polymorphisms with P<5×10^-8 were further prioritized using in silico analysis based on their exp

SUBMITTER: Singh S 

PROVIDER: S-EPMC5907544 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature