Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.

ABSTRACT: Vascular calcification and increased cardiovascular morbidity and mortality are closely related in patients with end-stage renal disease and diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays a crucial role in the regulation of apoptosis, fibrosis, angiogenesis, and other pathological disorders. There is evidence that specific protein 1 (Sp1) directly stimulates the transcription of bone morphogenetic protein 2 (BMP2) and that BMP2 plays a key role in the calcification process in the BMP2-expressing F9 cell model system. Here, we investigated whether Sp1 plays an important role in vascular calcification and its potential regulatory mechanism in vascular calcification. In this study, vascular calcification was induced in male Wistar rats by administration o

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5907546 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature