Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesis remains controversial.

Methods and results

We investigated the role of B cells and immunoglobulins in a murine model of AAA, induced with a periaortic application of CaCl₂, and in human AAA. Both human and mouse AAA tissue showed B-cell infiltration. Mouse AAA tissue showed deposition of IgG and activation of Syk, a key molecule in B-cell activation and immunoglobulin function, which were localized to infiltrating cells including B cells and macrop

SUBMITTER: Furusho A 

PROVIDER: S-EPMC5907549 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature