Relation of Insulin Resistance to Longitudinal Changes in Left Ventricular Structure and Function in a General Population.

ABSTRACT: Population data on the longitudinal changes of left ventricular (LV) structure and function in relation to insulin resistance are sparse. Therefore, we assessed in a general population whether hyperinsulinemia predicts longitudinal changes in LV and arterial characteristics. In 627 participants (mean age 50.7 years, 51.4% women), we assessed echocardiographic indexes of LV structure and function and carotid-femoral pulse wave velocity by applanation tonometry at baseline and after 4.7 years. We regressed longitudinal changes in these indexes on baseline insulin and its change during follow-up, and reported standardized effect sizes as a percentage of the SD of LV changes associated with a doubling of insulin. After adjustment, higher baseline insulin predicted a greater temporal increase i

SUBMITTER: Cauwenberghs N 

PROVIDER: S-EPMC5907600 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature