Derivation and internal validation of a mortality risk index for aged people living with HIV: The Dat'AIDS score.

ABSTRACT:

Objective

The objective was to develop a multivariable prognostic index for overall mortality over a five-year span integrating classical HIV biomarkers and comorbidities in people living with HIV (PLHIV) aged 60 or older.

Design

Prospective multicenter cohort study from the French Dat'AIDS cohort.

Methods

All HIV-1 infected patients aged 60 years or older on 1st January 2008 were included. Sociodemographic data, CD4 cell count, CD4 nadir, HIV viral load, history of comorbidities, hepatitis co-infections and laboratory parameters at baseline were considered as potential prognostic variables. Primary outcome was all-cause mortality.

Results

Among 1415 patients included, we derived a score comprising the following predictors: Age (65-74: 1 point; ≥75: 8 points),

SUBMITTER: Hentzien M 

PROVIDER: S-EPMC5908189 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature