Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.

ABSTRACT: The spatial architecture of signaling pathways and the interaction with cell size and morphology are complex, but little understood. With the advances of single cell imaging and single cell biology, it becomes crucial to understand intracellular processes in time and space. Activation of cell surface receptors often triggers a signaling cascade including the activation of membrane-attached and cytosolic signaling components, which eventually transmit the signal to the cell nucleus. Signaling proteins can form steep gradients in the cytosol, which cause strong cell size dependence. We show that the kinetics at the membrane-cytosolic interface and the ratio of cell membrane area to the enclosed cytosolic volume change the behavior of signaling cascades significantly. We suggest an estimate o

SUBMITTER: Giese W 

PROVIDER: S-EPMC5908195 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature